Abstract
Lipids and their metabolites are key molecular integrators of energy homeostasis and signaling. However, lipids are easily oxidized by reactive oxygen species, resulting in lipid peroxidation and metabolic products such as lipid-derived electrophiles. Lipid peroxidation produces hundreds of products and each of these performs a different function. It is challenging to detect and inhibit all of these products in vivo. The initial products of lipid oxidation are lipid-derived radicals, the most upstream products that can cause extensive chain reactions affecting lipid peroxidation. Hence, the ability to detect lipid radicals would provide information about one of most important class of molecules causing cellular and tissue damage in a wide range of diseases. In addition, inhibiting generation of lipid radicals could attenuate the damaging functions of hundreds of lipid metabolites. This would also provide information on the mechanism of diseases to guide development of new therapeutic strategies. In this poster, we will present the first fluorescence probe for lipid radicals, NBD-Pen, with high selectivity and sensitivity, that is suitable for cell imaging and for staining tissue sections.
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