Abstract
We recently demonstrated that Interferon Regulatory Factor 6 (IRF6) is a transcription factor essential for keratinocyte adhesion. Specifically, it is required for the recycling and delivery of E-cadherin to the plasma membrane. Interestingly, the total E-cadherin levels were not altered in the absence of IRF6, and under culture conditions used to test keratinocyte adhesion behavior, IRF6 was not detected in the nucleus. IRF6 protein includes a DNA binding domain (DBD), a protein binding domain (PBD), and a serine rich autoinhibitory region (SRR).
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