Abstract
The ductus arteriosus of the premature neonate is exquisitely sensitive to prostaglandins. Dilator prostaglandins 6 keto PGF1α, a stable metabolite of prostacyclin, and PGE2 were measured by a RIA in 15 infants with PDA. Left ventricular systolic time intervals (LVSTI) were measured by M-mode echocardiography. LVSTI ≤ 0.30 are associated with clinically significant ductal shunting. Mean 6 keto PGF1α levels in infants with more severe shunting (LVSTI≤0.30) were significantly higher than in those with a moderate level of shunting (776 ± 432 vs. 302 ± 115 pg/ml; p<0.05). Furthermore, a significant correlation was found between the extent of elevation of 6 keto PGF, and of decrease in LVSTI suggesting that both reflect the severity of left to right shunting. Elevated PGE2 levels and LA/Ao ratios, on the otheY hand, were not correlated with PDA severity.
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