Abstract
The typical MDR phenotype have been associated, among other signs, with reduced intracellular accumulation of MDR-causing drugs. We have studied the rubomicin (rub) and adriablastin (adr) accumulation by the fluorescent spectroscopy method. We have chosen, from our laboratory collection of P388 leukemia MDR-strains, vinblastine-resistant tumor (P388/vbl) possessed by MDR1 gene amplification and cross restistance to MDR causing drug and adriablastin-resistant tumor (P388/adr1) having incomplete pattern of cross resistance and no MDR1 gene amplification. There were moderate but constant differences in drugs accumulation between cells of sensitive and resistant strains. The rub and adr accumulation by P388/adrl cells was 2.1 and 1.3 times less than that observed in sensitive cells. These finding were I. 7 and 1. 3 for P388/vbl respectively. There were no differences of the parameter between resistant strains. Taken together the data suggest that several different mechanisms could participate even in case of classic MDR.
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