Abstract

This study was undertaken to evaluate the relationship between plasma and urinary CA and age, pulse rate, blood pressure and urinary Na+ excretion. 148 healthy children (aged 2d-14y) were tested for epinephrine (E) and norepinephrine (NE) urinary excretion (fluorimetric method). Basal plasma E, NE and dopamine (DA) were measured in 16 children (aged 4y-10y) by a radio-enzymatic assay. Blood was sampled in basal conditions. Values obtained were (X ± SE, range R), NE: 175.8 ± 13.69, R: 116.0-310.0; E: 98.7 ± 9.42, R: 53.0-168.0; DA: 988.0 ± 88.6, R:530.0 - 678.0,pg/ml. There was positive correlation (r: 0.63, p 0.005) between basal plasma NE and age. No correlation between NE, pulse rate and blood pressure and neither between E and DA and the mentioned parameters were found. The relationship between plasma CA and urinary Na+ showed a negative correlation for DA and Na+ (r: -0.56 p 0.05) while there was no correlation between E and NE and urinary Na+. NE urinary excretion 28.3 ± 1.38, (R:1.1-79.2ug/24hs) showed a positive correlation (r:0.63, p 0.002) with age. No correlation was found between urinary E and age. We can conclude: 1° studies in children should be aged-matched, 2°DA has a role in Na+ balance regulation.

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