14 Peripheral blood mononuclear cells from patients with SPAST hereditary spastic paraplegia (HSP-SPAST) show disease-associated effect of reduced acetylated α-tubulin

Abstract

ObjectivesHSP-SPAST is the most common form of hereditary spastic paraplegia (HSP). In vitro studies using HSP-SPAST patient-derived neurons have shown that reduced levels of acetylated α-tubulin in patient neurons leads...