Abstract
Publisher Summary This chapter discusses the adverse effects of dermatological drugs, topical agents, and cosmetics such as hair dyes, henna, pimecrolimus, and minoxidil. Previous studies have suggested an association between the use of hair dyes and some cancers. Several studies have found an association of nonHodgkin's lymphoma with the use of hair dyes. In recent years, contact dermatitis after henna tattoos has been attributed to the sensitizer paraphenylenediamine, which is used as an antioxidant and favours a long-lasting effect of the henna. Allergic contact dermatitis from pimecrolimus in a patient with tacrolimus allergy has been described, showing the possibility of cross-reactions among topical immunomodulators. There have been reports of hypotension and tachycardia after chronic scalp application of minoxidil, suggesting that topical minoxidil can be systemically absorbed. Phototherapy and photochemotherapy with aminolevulinic acid is also related to complications, pain is the main adverse effect of photodynamic therapy. Tretinoin application has led to sunburn, hypersensitivity reactions, contact dermatitis, and desquamation.
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