Abstract
AFTER a single injection of morphine or related narcotic analgesics, incorporation of 14C-tyrosine into 14C-catecholamines is increased markedly in the brains of mice1,2 and rats3. However, repeated administration of these drugs results in the development of tolerance to their effects upon 14C-catecholamine synthesis1,2. We have determined that once complete tolerance has developed, the mouse brain cannot maintain normal rates of catecholamine synthesis without the continued administration of morphine.
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