Abstract
A new, convenient and fast on-column method using a strong anion exchange resin as the solid state support has been developed for the on-line synthesis of nitrogen-13 ( T 1 2 = 9.96 min ) labelled cisplatin ([ 13N] cisplatin). The whole synthesis, including sterile formulation of the product, is accomplished within 15 min. Using this method, after optimization of the reaction parameters, carrier-added [ 13N] cisplatin ( 1) can be obtained ready for injection in a decay-corrected radiochemical yield of 80% with a specific radioactivity of 30 MBq/μmol and a radiochemical purity of >98%.
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