1,3-Dipolar cycloaddition reactions of azomethine ylides with seven-membered cyclic N-sulfony imines access to polycyclic sulfonamides

Abstract

Abstract A straightforward and efficient strategy for the synthesis of novel functionalized polycyclic sulfonamides containing e-sultams motif under metal-free catalysis via [3 + 2] 1,3-dipolar cycloaddition reactions of azomethine ylides generated in situ with seven-membered cyclic N-sulfony imines has been achieved. The present process was carried out under mild reaction conditions to give polycyclic sulfonamides in high yield (up to 95%). Additionally, the conversion of the cycloadduct to other useful structure has also been developed. The structure of the typical product was clearly established by X-ray crystallography.