Abstract
We provide an overview of 13 C magnetic resonance spectroscopy methods and their applications as an established metabolic tool with an emphasis on the use of high-resolution 13 C magnetic resonance spectroscopy and 13 C isotopomer analysis. Topics addressed include general properties of the 13 C magnetic resonance spectroscopy spec- trum; different 13 C magnetic resonance spectroscopy acquisition protocols; determination of fractional 13 C enrichment, kinetic, or steady state measurements of metabolic flux; 13 C isotopomer analysis approaches; 13 C( 2 H) magnetic resonance spectroscopy methodologies; and in vivo 13 C magnetic resonance spectroscopy. Some illustrative applications are
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