Abstract
The newborn is more resistant to the nephrotoxic effects of aminoglycosides. To determine if this resistance extends to other nephrotoxins, we studied the effects of UN (10 mg/kg IV) on renal function in dogs 1-2 wks (I) and 3-5 wks (II) of age during initiation (2 hrs) and in the maintenance phase (24 hrs after UN). Age matched controls received saline(S). The results are: 2 hrs post UN, there was extensive vacuolation only of the pars convoluta and greater in II than in I. 24 hrs post UN there were no distinct morphological changes (light & electron microscopy). Conclusion: very young puppies are more resistant to some nephrotoxins than older puppies and adult dogs.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
