1394P - The Relationship Between Preeclampsia, Pregnancy-Induced Hypertension and Maternal Risk of Breast Cancer: a Meta-Analysis

Abstract

ABSTRACT It has long been recognized that some human breast cancers are “hormone dependent”. Preeclampsia is a syndrome of pregnancy defined by the onset of hypertension and proteinuria and characterized by dysfunction of the maternal endothelium. Many hormonal changes occur with preeclampsia, and we hypothesize that these changes may influence the risk of maternal breast cancer. We also analyzed relation between PIH and maternal risk of breast cancer. Among 13 relevant publications about preeclampsia and 6 relevant publications about PIH, some studies might be associated with a lower risk of breast cancer, but others did not. Therefore these results are inconclusive. According to pooled results, reduced breast cancer risk with preeclampsia was not shown in our meta-analysis (HR = 0.86; 95% C.I = 0.73-1.01, p = 0.06); however, a trend toward reduced maternal risk of breast cancer was identified. The effect of PIH was similar to that of preeclampsia (HR = 0.83; 95% C.I = 0.66-1.06, p = 0.13). The results of this meta-analysis suggest that preeclampsia and PIH do not significantly decrease the maternal risk of breast cancer. Disclosure All authors have declared no conflicts of interest.