Abstract
Cutaneous squamous cell carcinoma (cSCC) exhibits overall favorable prognosis with most cases cured by surgical intervention. However, due to an annual incidence of nearly 1 million patients diagnosed, the estimated deaths attributed to cSCC approach or surpass those from melanoma. Management decisions for high-risk cSCC are complicated by the limited accuracy of current staging systems, highlighting a need for additional prognostic biomarkers. The objective of this study was to develop a gene expression profile (GEP) test that identifies patients at low or high risk for nodal or distant metastasis.
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