1380P High Sonic Hedgehog (HH) signalling activity, low androgen receptor activity and clonal evolution are associated with resistance to androgen-receptor axis inhibitors in patients with metastatic prostate cancer

N Menssouri,Y Wesseling-Rozendaal,L Poiraudeau,C Helissey,L Bigot,J Sabio,T Ibrahim,C Nicotra,L Tselikas,E Colomba,P Lavaud,B Besse,J-Y Scoazec,E Den Biezen,S Neerken,K Fizazi,D Gautheret,P Van De Wiel,Y Loriot

doi:10.1016/j.annonc.2022.07.1512

1380P High Sonic Hedgehog (HH) signalling activity, low androgen receptor activity and clonal evolution are associated with resistance to androgen-receptor axis inhibitors in patients with metastatic prostate cancer

N Menssouri, Y Wesseling-Rozendaal + Show 17 more

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https://doi.org/10.1016/j.annonc.2022.07.1512

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Journal: Annals of oncology : official journal of the European Society for Medical Oncology	Publication Date: Sep 1, 2022
License type: publisher-specific-oa

#Metastatic Prostate Cancer #High Sonic Hedgehog + Show 8 more

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Abstract

The androgen-receptor pathway inhibitors (ARPI) are standard treatment of metastatic castration-resistant prostate cancer (mCRPC). However, the mechanisms of both primary and acquired resistance remain largely unknown.

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