138 Successful Treatment of Residual Curvature in Peyronie's Disease in Men Previously Treated with Intralesional Clostridium Collagenase Histolyticum

Abstract

Intralesional clostridium collagenase histolyticum (CCH) injection into the Peyronie's plaque is a treatment option for men with dorsal and dorsolateral curve with no hourglass deformity. The success and feasibility of surgically correcting residual curvature after intralesional CCH remains poorly characterized. We performed a retrospective analysis of patients who had intralesional CCH treatment for Peyronie's disease (PD) who subsequently underwent penile plication (PP), plaque incision and grafting (PIG), or inflatable penile prosthesis (IPP) placement as part of their treatment for residual curvature. Nine men who underwent PP, PIG, or IPP for the treatment of residual curvature after intralesional CCH were identified (Table 1). Six patients underwent PP, one patient underwent PIG and two patients underwent IPP with ancillary straightening maneuvers. The mean time (in days) from the last CCH injection to surgical correction was 128.9. The mean pre-CCH curvature was 69.4 degrees and the mean post-CCH curvature was 52.78 degrees. Seven out of nine patients had no residual curvature after surgical treatment. Increased fibrosis with increased surgical difficulty was noted in three out of ninr patients. No post-operative complications were noted.