138-POS

Abstract

Objectives The study is intended to analyze determining factors of successful conservative treatment of preeclampsia before 34 weeks of gestation. Methods This is a retrospective analytic observational study. Data were retrieved from medical records of patients admitted to Obstetric Ward of Dr Soetomo Hospital, from July to August 2013. The population of the study was patients with severe preeclampsia going through conservative treatment from January 2008 to December 2012. The inclusion criteria included population with complete medical record and without renal disease, SLE, premature rupture of membrane, and IUGR. The dependent variable in this study is the successful or unsuccessful conservative treatment for severe preeclampsia and the independent variables are gestational age, Esbach protein level, albumin serum level, uric acid level, blood pressure stage, Resistance Index and Pulsatility Index of uterine artery Doppler velocimetry, body mass index, parity, and maternal age. Double regression logistic analysis test was used with significant value if the p n = 15) and those with severe preeclampsia who failed conservative treatment ( n = 43, controls). Results Gestational age was significantly different ( p p = 0.003); the ROC curve obtained a cutoff point value of gestational age 31.5 weeks with sensitivity of 80% and specificity of 76.72%. Therefore, gestational age can be used as a determining factor for conservative treatment. Other determining factors were not significantly different ( p p = 0.226, uric acid p = 0.225, blood pressure p = 0.140, uterine artery PI p = 0.358, uterine artery RI p = 0.292, parity p = 0.133, serum albumin p = 0.943, serum creatinine p = 0.699, body mass index p = 0.962, and maternal age p = 0.589. Conclusions Gestational age is a determining factor for the success of conservative treatment of severe preeclampsia. Disclosures Y. Septivera: None. E. Ernawati: None. M.A. Akbar: None. A. Sulistyono: None. A. Aditiawarman: None. H.T. Joewono: None. E.G. Dachlan: None.