138 Copy number gain at chromosome 7q21 potentiates the large cell transformation in cutaneous T cell lymphoma

Abstract

Mycosis fungoides (MF), the most common type of cutaneous T cell lymphoma (CTCL), may undergo large cell transformation (LCT), which is related to aggressive clinical courses and resistance to conventional treatments. However, the mechanisms of LCT remain largely unknown. To explore the molecular pathogenesis underlying the transformation of MF, we performed whole-transcriptome sequencing (RNA-seq) followed by integrated deep analyses on lesional biopsies from 49 tumor-stage MF patients, including 26 patients with LCT and 23 patients without LCT (NLCT).