137P Combining protein and mRNA spatial profiles to identify distinct cell population in metaplastic breast cancer

Abstract

Metaplastic breast cancer (MpBC) is a heterogeneous disease and is characterized by the differentiation of the neoplastic epithelium into squamous cells and/or mesenchymal elements. MpBC is rare but very aggressive and presents high rates of recurrence, poor survival outcomes, and poor response to current chemotherapies optimized for other breast cancer subtypes. To date, there are no established treatments for MpBCs, due to paucity of clinical trials and near absence of preclinical models for investigation.