1373-P: Variables in Depression Screening Using PHQ-9 and PROMIS in Adolescents with T1DM

Abstract

Background: Depression in teens with type 1 diabetes (T1DM) is associated with poor disease management. Multiple depression screening questionnaires are validated in teens with chronic disease; no ideal instrument has been identified. Methods: Subjects aged 11 - 17 years with T1DM, completed the PROMIS and PHQ-9 on the same day (n=20), within 3 months (n=17), or within 6 months (n=11). PHQ-9 was completed by the subject and PROMIS was completed by the subject (PROMIS-Ch) and a parent (PROMIS-P). 1-way ANOVA determined statistical significance. Results: 1. Subjects with no or mild risk of depression on PHQ-9 had a PROMIS-Ch or PROMIS-P score >1.5 SD. 2. Clinical evaluation confirmed risk for depression in 5/6 subjects with moderate/severe risk on PHQ-9. PROMIS-Ch >1.5 SD in 2/5 subjects and PROMIS-P score >2 SD in 1/5 subjects. 3. Mean PHQ-9 score of 4 subjects with documented suicidal ideation (SI) was 18.4 (±6.7). The PROMIS-Ch was >1.5 SD in 2 of 4; PROMIS-P was >1.5 SD in 1 of 4. Conclusions: Both surveys distinguished children at moderate/severe risk of depression from those with no/mild risk. Neither PROMIS survey distinguished between children who were at mild or no risk on PHQ-9. Those with SI had mean high risk PHQ-9 score, but did not have consistently high risk PROMIS scores. When screening for depression in adolescents, PHQ-9 had a higher sensitivity when compared to PROMIS. Disclosure S. Nadella: None. S.P. Fritz: None. A.B. Muir: None.