137 MATHEMATICAL APPROACH TO THE SELECTION OF THE BEST DIAGNOSTIC PROCEDURES IN NEONATAL SEPTICAEMIA

Abstract

Early diagnosis of neonatal sepsis is the main factor in prognosis. Therefore we tried to find the best diagnostic tests using the mathematical methods. In 25 neonates with sepsis of late onset and 20 healthy ones discriminant analysis was performed taking into consideration the following parameters: mini-ESR, WBC, immature/total neutrophils, IgG, IgA, IgM levels. Additionally chemiluminescence (CL) in whole blood after latex stimulation in 3 doses (0.2, 0.05, 0.02 μl) was measured. Depending on the value of WBC the septic neonates were divided into 2 groups: I> 12 000/mm3, II < 12 000/mm3. In group I the significantly discriminating parameters for Fo = 4.13 and DF=1;35 appeared: mini-ESR (F = 21.06), WBC (F=9.15) and IgG level (F = 7.66), while in group II for Fo = = 4.13 and DF = 1;30 the only parameter was WBC (F = = 10.25). The percentage of correct classification for the I and II group respectively was as following: control - 95.2 and 66.7, sepsis - 86.6 and 80.0, total - 91.7 and 70.0. On the above outcome the discriminant function was defined. Simultaneously performed measurements of CL showed the decrease or quenching of the neutrophils activity. The results justify the necessity of further researches and the need of including CL into discriminant analysis.