137 Early neonatal outcome of newborns with mothers hypothyreosis in pregnancy

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<h3></h3> Newborns of mothers with hypothyroidism (latent or manifest) in pregnancy were investigated during two one-year periods. The aim was to point out particularities in mother’s anamnesis, pregnancy and labour, as well as the clinical characteristics of neonates (Apgar score, gestational age, birth weight, mode of delivery) and to compare the differences in two periods. <h3>Subjects</h3> The research was conducted on newborns of mothers with hypothyroidism in pregnancy in the Clinical Hospital Centre Osijek in 2015 and 2018. The control group consisted of newborns first born afterwards. The data were presented in tables, in absolute and relative frequencies. Chi-square test was used to demonstrate the statistical significance, resulting in significance level of p &lt; 0.05. It was retrospective case control study. Mothers with hypothyroidism in pregnancy had more acute complications in pregnancy (infections, hypertension, pre-eclampsia, gestational diabetes) and delivery, and more complications in reproductive anamneses. Urgent Caesarean section was much more common for their newborns. C-reactive protein among them was often higher than 5 mg/l. They gave birth prematurely more often, while infections, cyanosis, hypo- and hypertonus, and jaundice were also more common. Complications of prematurity and the need for oxygenation occurred much more often than in the control group. They were also hospitalized longer. Comparing the two one-year periods, we found less complications during pregnancy and delivery in the year 2018; the frequency of mothers with bad reproductive anamnesis was three times lower, as was the number of urgent Caesarean sections. The number of newborns born prematurely was two times smaller. In 2018, neonatal outcome included three times less common onset of infection, cyanosis, hypo- and hypertonus, and less common preterm labour. The need for oxygenation was five times, and for prolonged hospitalisation nine times less common. <h3>Conclusion</h3> Better perinatal care and screening of mothers with hypothyroidism improves neonatal outcome as well as long-life consequences in newborns and lowers the complication rates for mothers during pregnancy and delivery.