136-POS

Abstract

Objectives To evaluate blood pressure and renal function in the first year postpartum in women who developed severe preeclampsia (PE). Methods This prospective study included previously healthy women who developed preeclampsia during pregnancy. Blood pressure levels, ambulatory blood pressure monitoring (ABPM), and laboratory tests to assess kidney function, proteinuria and microalbuminuria were evaluated at 3, 6, and 12 months postpartum. Results 97 patients had outpatient follow-up. 29.3%, 24.1% and 19% at 3, 6, and 12 months postpartum, respectively, still had high blood pressure. Nineteen patients underwent ABPM with 6 and 23 with follow-up at 1 year. In ABPM at 1 year, 60.9% had altered result, with standard no dipper observed in 30.4% and 30.5% remaining, with altered values of SBP or DBP at some period evaluated. Proteinuria remained positive in 12.5%, 2.8% and 6.6% of patients at 3, 6 and 12 months postpartum, respectively. Albuminuria was seen in 28.9%, 17.5% and 15.3% of patients at 3, 6 and 12 months, respectively. After 3 months of delivery, 28.4% of patients maintained use of antihypertensive medication, 26.2% at 6 months, and 19.2% at one year. Sixty-two patients were available for analysis of proteinuria or microalbuminuria and measures of office BP or ABPM after 6 months of follow-up. Among these, only 61.3% of patients had normal BP and urinary protein loss; 12.9% had proteinuria or albuminuria with high normal BP; 14.5% had elevated BP and normal proteinuria and/or albuminuria; and 11.3% had proteinuria and/or albuminuria with elevated BP that remained high at the final assessment. Conclusions At 12 weeks postpartum we did not observe the normalization of blood pressure and proteinuria in a large proportion of women with severe PE. These changes suggest the increased cardiovascular risk in this population. Disclosures R.A. Costa: None. V.D. Silva: None. D.B. Dias: None. R.P. Rocha: None. L.C. Martin: None. J.C. Peracoli: None.