Abstract
Background: TCR repertoire of TILs is increasingly used as a fingerprint for identifying unique immune responses to cancer and as a biomarker for prognosticating clinical course and response to immunotherapy. Methods: CD8+ tumor infiltrating lymphocytes (TILs) obtained from fresh basal cell carcinoma (“BCC”) tumor specimens from nodular subtype (“nBCC”, n=6) versus infiltrative subtype (“iBCC”, n=6) were subject to single-cell VDJ profiling. Data were analyzed using iCellR and ImmunArch. Results: Pooled CD8+ TILs from nBCC and iBCC generated a significantly more diverse TCR repertoire than CD8+ T cells from healthy skin, but a significantly less diverse repertoire than CD8+ from healthy PBMCs.
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