135-POS

Abstract

Objectives To determine maternal and perinatal outcomes according to mode of delivery in normotensive and hypertensive pregnant women with term gestation, a live fetus, and undergoing induction of labor with misoprostol. Methods We conducted a retrospective cohort study from June 2004 to June 2011. The outcomes were tachysystole syndrome, uterine hyperstimulation, indications for cesarean section, severe maternal morbidity (uterine rupture and uterine atony), side effects, maternal death, Apgar scores at first and fifth minutes, neonatal death, need for admission at neonatal intensive care unit (NICU) and birth weight (grams). For statistical analysis we used the chi-square test or Fisher’s exact test, as appropriate, at a significance level of 5%. We also calculated the risk ratio (RR) and its confidence interval 95 % (95% CI). Results We evaluated 410 pregnant women submitted to induction of labor with misoprostol, 227 in normotensive, and 183 in hypertensive gestation. The main indication for induction of labor was hypertension (44.6%), followed by prolonged pregnancy (40.2%) and premature rupture of membranes (7.3%). Gestational hypertension was the most frequent (31.7%) cause, between hypertensive disorders. In both groups the failure of induction was the main indication for cesarean section, and there were no significant differences in maternal outcomes according to the mode of delivery. Among perinatal outcomes, only the Apgar below seven in the first minute occurred less frequently when the patient had a vaginal delivery in the group of normotensive women (RR 0.41, 95% CI 0.18–0.90). Conclusions Maternal and perinatal outcomes were similar in both normotensive and hypertensive pregnant women undergoing labor induction with misoprostol. Disclosures N.V. Leal: None. A.S. Souza: None. L. Katz: None. C. Noronha-Neto: None. S.B. Maia: None. A.H. Franca-Neto: None. M.M. Amorim: None.