Abstract

Immune checkpoint inhibitors combined with platinum doublet chemotherapy (PDCT) have improved outcomes for NSCLC; however, some patients with metastatic NSCLC may not benefit from this strategy due to intrinsic or acquired resistance. Lymphocyte-activation gene 3 (LAG-3) is a inhibitory immune checkpoint that is a marker of T-cell exhaustion limiting their activity. RELA is a LAG-3-blocking monoclonal antibody that restores effector function in exhausted T cells. The combination of RELA + NIVO demonstrated superior progression-free survival (PFS) benefit in previously untreated melanoma and was well tolerated with no new safety signals.

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