1355-P: Risk of Chronic Kidney Disease in Early-Onset Type 2 Diabetes in Mexico

Abstract

Patients with early onset type 2 diabetes (EOD) seem to be at increased risk of developing complications. Screening and diagnosis for CKD is poorly executed in primary care (PC) of low-and-middle income countries. Thus, we aimed to analyze the presence of CKD in EOD in comparison with later-onset diabetes (LOD). Data were obtained from the largest cohort of patients with T2D evaluated for CKD within the PC in Mexico (DIABEMPIC). EOD and LOD were defined as the age of diagnosis <40 and ≥40 years, respectively. CKD assessment included albuminuria through urinary albumin-creatinine ratio (≥30mg/g for CKD) and estimated glomerular filtration rate (eGFR≤60 ml/min/1.73m2 for CKD). A total of 1,592 patients were included. The burden of CKD at different diabetes durations are shown in Table 1. The prevalence of overall CKD was significantly higher in the EOD group (p<0.008), associated to a greater presence of albuminuria; a higher prevalence of albuminuria was observed after 10 years of diagnosis in the EOD (p<0.0001). In the univariate analysis, EOD was associated with an increased risk of CKD (OR 1.33, 95%CI 1.08-1.65). In conclusion, EOD patients presented a higher risk of CKD, particularly on account for albuminuric-CKD phenotype, even though they are comparatively younger. Our results enhance the need for the management of risk factors and proper screening of CKD in T2D, especially in EOD, in PC settings, and through albuminuria measurement. Disclosure R.Silva-tinoco: Speaker's Bureau; AstraZeneca, Boehringer Ingelheim Inc., Novo Nordisk. J.Mejia-vilet: None. J.Ochoa-moreno: None. J.Serna: None. O.Lopez-arellano: None. T.Cuatecontzi-xochitiotzi: None. E.B.Guzman-olvera: None. V.Delatorre-saldaña: None. A.Galindez-fuentes: None. L.Castillo-martinez: None. F.Bernal-ceballos: None. V.Rios-carbajal: None. N.Torres-sandoval: None.