Abstract

YAP and TAZ are critical downstream effectors of the hippo signaling pathway, which play pivotal roles in controlling organ size and maintaining tissue homeostasis. Although dysregulation of YAP/TAZ has been linked to various human diseases their role in dermal extracellular matrix (ECM) regulation remains largely unknown. Here, we describe the role of YAP/TAZ in mouse dermal ECM maturation during early postnatal development We find that from birth (P0) to postnatal day 20 (P20), skin surface area increases 6-fold (N=6).

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