135 Silencing Quorum Sensing molecule mechanisms to reduce harmful effects of two pathogenic bacteria on the skin

Abstract

Bacteria use cell to cell communication system called quorum sensing (QS) to share information about cell density and to adjust gene expression accordingly. Processes controlled by QS include biofilm formation, virulence factor secretion and swarming, responsible for bacteria harmful expression on the skin. Here we observed QS expression of two opportunistic skin bacteria: S. aureus (Sa) and P. aeruginosa (Pa). Sa strongly disturbs the skin barrier function by secreting lipase and forming a biofilm.