Abstract
BACKGROUND: How chronic UV exposure changes clonal dynamics and expands genomic diversity in the initiation and progression of skin cancer remains unclear. Here we describe our initial findings characterizing clonal dynamics and transcriptional signatures in response to chronic UV exposure by multicolor lineage tracing. We interpret our results in a framework of carcinogenesis in which initial heritable genomic changes then require sufficient cell turnover and release from normal tissue constraints to form tumors.
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