Abstract
Mineralization of trabecular bone changes more rapidly than that of cortical bone which alters in thickness rather than density. A separate determination of cortical thickness, cortical density and trabecular density would be desirable. Current methods do not allow this. Radiography yields measurements of cortical thickness only, while γ-ray absorption technique (Cameron) measures the total mineral content. We have approached the problem by combining the photon absorptiometry with CAT which is used successfully to study the brain (EMl-scan). With this technique a cross-sectional image of the bone can be constructed and thickness and density of cortical bone in the diaphysis as well as density of trabecular bone in the metaphysis can be quantified. - So far our study has been focused on trabecular density at the distal metaphysis of the radial bone in children older than 4 years and in adults. Preliminary results indicate that the values are not age dependent but that there is a great individual variation. However, there is a variation in the order of only 2% between left and right arm and between repeated measurements over 60 days in healthy individuals. Immobilization of the arm in a cast (fracture) results in a massive drop in trabecular bone density within 2 to 3 weeks. In children with advanced renal Insufficiency decreased as well as increased values have been found.
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