Abstract
Carriers of BRCA1/2 pathogenetic variants are at increased risk of developing breast, tube/ovarian and other typical cancers of the hereditary spectrum. Secondary and primary prevention are the main strategies for the management of at-risk subjects. Intensified surveillance allows to identify early-stage cancers. Risk-reducing mastectomy and salpingo-oophorectomy decrease the incidence of primary cancers, the latter also decreases mortality.
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