1341 CHARACTERISTICS OF ANTERIOR PREDOMINANT PROSTATE CANCER AND THE USEFULNESS OF MULTIPARAMETRIC MRI IN DIAGNOSIS

Abstract

You have accessJournal of UrologyProstate Cancer: Localized (VI)1 Apr 20131341 CHARACTERISTICS OF ANTERIOR PREDOMINANT PROSTATE CANCER AND THE USEFULNESS OF MULTIPARAMETRIC MRI IN DIAGNOSIS Sahyun Pak, Sejun Park, Sang Hoon Song, Dalsan You, Cheryn Song, and Hanjong Ahn Sahyun PakSahyun Pak Seoul, Korea, Republic of More articles by this author , Sejun ParkSejun Park Seoul, Korea, Republic of More articles by this author , Sang Hoon SongSang Hoon Song Seoul, Korea, Republic of More articles by this author , Dalsan YouDalsan You Seoul, Korea, Republic of More articles by this author , Cheryn SongCheryn Song Seoul, Korea, Republic of More articles by this author , and Hanjong AhnHanjong Ahn Seoul, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.03.052AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES In prostate-specific antigen(PSA) era, late detection of prostate cancer still exists when the tumor arised from anterior portion of prostate. We analyzed the characteristics of anterior predominant prostate cancer, and assess the usefulness of MRI to detect the tumor preoperatively. METHODS We evaluated clinicopathological data and radiologic findings of 660 patients treated with radical prostatectomy between July, 2007 and June, 2012. All patients underwent MRI with diffusion-weighted imaging, and ADC mapping. When the lesion was larger than 8mm in diameter, showed low signal intensity on T2-weighted image, restricted diffusion on diffusion-weighted images and ADC maps, it was considered presence of tumor. RESULTS Anterior predominant prostate cancer constituted 26.8% of total patients. Index tumor in anterior peripheral zone, anterior fibromuscular stroma, and transition zone were 27.7%, 3.4%, and 69.0% respectively. Age, BMI, PSA, prostate volume, and PSA density in anterior predominant prostate cancer were not different from posterior prostate cancer. Diagnosis with repeated biopsy was more frequent in anterior predominant cancer, and clinical T stage (p<0.001), pathologic T stage (p<0.001), pathologic GS (p=0.040) were lower. In D'Amico low-risk patients, anterior predominant cancer presented in 40.1%, and upgrading was more frequently observed than posterior predominant cancer (65.1% vs 49.5%, p=0.027). In anterior predominant cancer, sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of MRI were 64.2%, 83.0%, 63.8%, 83.2%, and 77.0%, respectively. CONCLUSIONS Anterior predominant cancer had favorable pathologic features compared with posterior dominant cancer. However, more frequent upgrading was noted. MRI was useful to detect the hidden anterior predominant cancer. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e548 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sahyun Pak Seoul, Korea, Republic of More articles by this author Sejun Park Seoul, Korea, Republic of More articles by this author Sang Hoon Song Seoul, Korea, Republic of More articles by this author Dalsan You Seoul, Korea, Republic of More articles by this author Cheryn Song Seoul, Korea, Republic of More articles by this author Hanjong Ahn Seoul, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...