Abstract
The aim is to examine the resting state functional connectivity (RSFC) between the two hemispheres and its relationships with clinical characteristic in idiopathic generalized epilepsy with generalized tonic–clonic seizures only (IGE-GTCS) patients using a technique called “voxel-mirrored homotopic connectivity (VMHC)”.The resting-state functional MRI (Rs-fMRI) was used to measure the RSFC in patients with IGE-GTC and age–gender matched healthy subjects. The between-group difference in interhemispheric RSFC was examined after the interhemispheric RSFC map was obtained by an automated VMHC approach.Compared to the controls, the IGE-GTCS patients showed significant increases in VMHC in the bilateral anterior cingulate and medial prefrontal gyrus. No areas showed decreased VMHC in patients. Moreover, the VMHC in bilateral thalamus, orbital frontal cortex as well as cerebellum showed significant negative correlations with the illness duration.The current findings provide preliminary evidence of increased interhemispheric RSFC in patients with IGE-GTCS during the interictal period. These VMHC deficits in these regions and the inverse relations between VMHC and clinical characteristic may play an important role in the pathophysiology of IGE-GTCS. Our study may contribute to the understanding of neuro-pathophysiological mechanism of epilepsy and psychosocial function impairments in patients with IGE-GTCS.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
