133-POS

Abstract

Objectives Women with a history of preeclampsia have an increased risk for future cardiovascular disease (CVD). Why only some women are affected by CVD after severe preeclampsia is not known. The objective of this study was to examine the presence of CVD among women after severe preeclampsia, and illuminate any differences between the women with present CVD and women without CVD. Methods Women admitted to Danderyd Hospital, Stockholm, Sweden with the diagnosis of severe preeclampsia (O141 A, B, C and X) in 1999–2001 were invited to participate. Out of 60 women where the diagnosis was correct, 36 women agreed to participate. Blood pressure, lipids waist circumference and body mass index (BMI) were registered. Participants filled in a form concerning family history, diseases, tobacco, reproduction, physical activity, sleeping patterns, weight change, and marital stress. Family history of CVD was defined as having one first degree relative with stroke, myocardial infarct, hypertension, peripheral vascular disease or diabetes type 2 before the age of 55 (men) and 65 (women). Stress in relation was measured with Stockholm Marital Stress Scale (SMSS) and sleep with Epworth Sleepiness Scale (ESS). Results Ten women were already affected by CVD and 26 were not. Affected women had significantly higher systolic ( p = 0.001) and diastolic ( p = 0.001) blood pressure (in spite of medication), BMI ( p = 0.022) and waist circumference ( p = 0.003) as well as higher levels of apoB ( p = 0.017) and lower levels of apoA1 ( p = 0.015). A difference was also seen in family history of CVD, number of preeclamptic pregnancies, sleep and marital stress but results were not significantly different in this small pilot study. Conclusions Constitutional differences when becoming pregnant, number of preeclamptic episodes, obesity, as well as lifestyle may all influence the risk for later CVD. Disclosures E.G. Andolf: None. C. Iacobaeus: None. I. Nord: None.