Abstract
To correlate the severity of CH and its associated cerebral hemodynamic changes with long-term outcome, we prospectively evaluated survivors with birth weight ≤1500 gnu The population was drawn from 155 low birth weight inborn infants who were assessed for CH by echoencephalography and for abnormal cerebral blood flow velocity (CBFV) patterns by Doppler ultrasound technique. Of these 155 infants, 100 survived; 70 returned for child development evaluation at a mean age of 16 ± 5 mo; in 40, valid Bayley scores were obtained. The incidence of neurological handicaps was higher with those with CH (47%) vs those with no CH (26%). The table shows that incidence of moderate to severe handicaps was highest with Grade 3-4 CH. Abnormal neurological findings were observed in 13/42 (31%) who had normal CBFV patterns and in 15/28 (54%) who had pulsatility index values ≥ .90 during the first week of life (p 0.05). The mean mental development index (MDI) corrected for gestational age was 84 ± 24 in the CH and 96 ± 12 in no-CH group. 10/24 had MDI <80 in the CH babies compared to 0/15 in no-CH babies (X2 = 8.4 df = 1 p <.005). Preliminary data show that the severity of CH and abnormal CBFV patterns appear to correlate with long-term outcome.
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