Abstract
Neutrophils are the first immune cells to reach inflamed sites and have been reported to contribute to the pathogenesis of many inflammatory skin diseases such as psoriasis, skin cancers, hidradenitis suppurativa and others. Yet, little is known about (i) the spatiotemporal pattern of neutrophil infiltration in inflamed skin in vivo after acute and recurrent irritation, and (ii) the source and identity of the signals responsible for neutrophil recruitment to stressed skin. We hypothesized that epidermal keratinocyte-derived signals mediate the recruitment of neutrophils to skin after topical exposure to irritants, and that the pattern of neutrophil infiltration in skin differs upon repeated exposure due to changes in signal(s) from stressed keratinocytes.
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