Abstract
Background: cGAS-STING, which monitors cytosolic DNA and triggers innate immune response, has recently attracted attention as a molecular target to sensitize cancer to immune therapies. Micronuclei generated by aberrant mitosis are known to profoundly activate the cGAS-STING pathway in cancer cells when they leak into the cytoplasm. We have validated that small-molecule inhibitors targeting centromere-associated protein-E (CENP-E) generate micronuclei through chromosome misalignment and mitotic slippage.
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