Abstract
To determine the clinically important mechanisms of multidrug resistance, we studied the expression of the MRP gene in primary colorectal carcinomas (N = 75). MRP RNA was determined by RT-PCR. MRP RNA was detected in 62 (83%) tumor specimens. The expression was independent of size and localization of the primary tumor, lymph node involvement, tumor stage and the survival durations of the patients. However, MRP gene expression correlated with MDRI gene expression. In conclusion, the frequent expression of the MRP gene suggests its importance as a drug resistance gene in colorectal carcinomas. (Supported by Austrian Science Foundation.)
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