Abstract
Previously we have demonstrated subnormal ACTH response with low basal ACTH level and normal basal cortisol level to i.v. metyrapon in hypothalamicpituitary hypofunction (21st Ann.Meet.of ESPE, Helsinki, 1982). The purpose of our present study was to asses the ACTH-cortisol responsiveness to CRF in the same patients. Human CRF (1-41) - hCRF (Bissendorf) - was given i.v. in the dose of 1 μg/kgbw at 8.00 a.m. after an overnight fast. Basal levels of ACTH (pg/ml) and cortisol (μg/100 ml) were measured before and 30, 60 and 90 minutes after hCRF application. In 5 patients with “ACTH-deficiency” (according to the i.v. metyrapon test) hCRF induced a detectable rise of ACTH, followed by an increase of cortisol secretion (Tabl.I). In 2 patients there were no significant changes of ACTH and cortisol levels.
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