132 Delayed cord clamping's effect on blood sugar levels in neonates exposed to late-preterm antenatal steroids

Abstract

Neonatal hypoglycemia is a known side effect of antenatal betamethasone (BMZ) given for fetal maturation. We sought to investigate if delayed cord clamping (DCC) has an impact on neonatal hypoglycemia induced by late preterm BMZ administration. A retrospective cohort study (January 2019-May 2019) of pregnancies undergoing delivery between 34-0/7 and 36-6/7 weeks at a single center divided in 2 groups: DCC + BMZ and BMZ-only (no DCC). The primary outcome was the occurrence of neonatal hypoglycemia at the 1st hour after delivery. A total of 62/188, 32.98% (DCC+BMZ) and 45/100, 45% (DCC-only) infants presented with hypoglycemia at 1-hour after birth (adjusted P=0.06; OR 0.73, 95% CI 0.54-1.01). When stratified according to gestational age at delivery, DCC was associated with a 46% reduction in the occurrence of neonatal hypoglycemia among those born at 35-0/7 to 35-6/7 weeks (adjusted P=0.03343; OR 0.54, 95% CI 0.33-0.88) and 35% reduction among those born at 36-0/7 to 36-67 weeks (adjusted P=0.04619; OR 0.65, 95% CI 0.43-0.97). In our cohort, delayed cord clamping protects from early neonatal hypoglycemia in infants receiving late preterm BMZ born between 35-0/7 and 36-6/7 weeks’ gestation.View Large Image Figure ViewerDownload Hi-res image Download (PPT)