1314 NEGATIVE IMPACT OF AGING ON THE GANGLIONIC NEURON COUNT AROUND THE HUMAN PROSTATE

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Evaluation1 Apr 20111314 NEGATIVE IMPACT OF AGING ON THE GANGLIONIC NEURON COUNT AROUND THE HUMAN PROSTATE Shin-ichi Hisasue, Kohei Hashimoto, Yohei Matsuda, Hisanori Taniguchi, Masahide Kanaya, Satomi Fujii, Satoshi Takahashi, and Taiji Tsukamoto Shin-ichi HisasueShin-ichi Hisasue Sapporo, Japan More articles by this author , Kohei HashimotoKohei Hashimoto Sapporo, Japan More articles by this author , Yohei MatsudaYohei Matsuda Sapporo, Japan More articles by this author , Hisanori TaniguchiHisanori Taniguchi Osaka, Japan More articles by this author , Masahide KanayaMasahide Kanaya Sapporo, Japan More articles by this author , Satomi FujiiSatomi Fujii Kutchan, Japan More articles by this author , Satoshi TakahashiSatoshi Takahashi Sapporo, Japan More articles by this author , and Taiji TsukamotoTaiji Tsukamoto Sapporo, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1134AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES We recently reported that baseline erectile function greatly influences cavernous nerve quantity and distribution around the prostate (Hisasue et al. J. Urol. 2010). Ganglionic neurons also surrounded the prostate and are believed to be responsible for the axonal regeneration or collateral sprouting of cavernous nerve. We assessed which factor predicts the ganglionic neuron count around the human prostate METHODS We investigated 46 hemispheres of 23 non-nerve sparing radical prostatectomy specimens. We performed immunohistochemical staining with nNOS-antibody, and divided the prostatic hemisphere into six zones to assess the distribution of nNOS-positive ganglionic neurons at the apex, midportion and base of the prostate. Multivariate analysis of quantity of the overall neurons used the variables of patient age (<65 years vs. ≥65 years), specimen weight (≥40g vs. <40g), body mass index (<25 kg/m2, ≥25 kg/m2), and maximum penile circumferential change using erectometer (MPCC; ≥20mm, <20mm). RESULTS Median patient age was 68 years (range 57 to 74). Median MPCC was 25.0mm (range 2.70 to 38.3). Logistic regression analysis revealed that the age was the single significant variable (p=0.046). The ganglionic neuron count was lower in the older (≥65 years) group than in the younger (<65 years) group (p=0.048; Mann-Whitney U-test). The neuron count was significantly different between the two groups in the 4 to 5 o′clock area at the mid-prostate. CONCLUSIONS This is the first study indicating that higher age has a negative impact on the nNOS-positive ganglionic neuron count in human. This result will lead to the rationale why older people show the poor outcome in their recovery of erection following radical prostatectomy. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e525-e526 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Shin-ichi Hisasue Sapporo, Japan More articles by this author Kohei Hashimoto Sapporo, Japan More articles by this author Yohei Matsuda Sapporo, Japan More articles by this author Hisanori Taniguchi Osaka, Japan More articles by this author Masahide Kanaya Sapporo, Japan More articles by this author Satomi Fujii Kutchan, Japan More articles by this author Satoshi Takahashi Sapporo, Japan More articles by this author Taiji Tsukamoto Sapporo, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...