1312 CHANGES IN RENAL FUNCTION AFTER RENAL SURGERY AND THE ANALYSIS OF FACTORS AFFECTING THE DEVELOPMENT OF CHRONIC RENAL INSUFFICIENCY; MULTICENTER STUDY

Abstract

You have accessJournal of UrologyKidney Cancer: Localized (II)1 Apr 20131312 CHANGES IN RENAL FUNCTION AFTER RENAL SURGERY AND THE ANALYSIS OF FACTORS AFFECTING THE DEVELOPMENT OF CHRONIC RENAL INSUFFICIENCY; MULTICENTER STUDY Yong Sun Choi, Yong Hyun Park, Yong-June Kim, Seok Ho Kang, Seok-Soo Byun, Hyo Sin Kim, and Sung-Hoo Hong Yong Sun ChoiYong Sun Choi Seoul, Korea, Republic of More articles by this author , Yong Hyun ParkYong Hyun Park Seoul, Korea, Republic of More articles by this author , Yong-June KimYong-June Kim Seoul, Korea, Republic of More articles by this author , Seok Ho KangSeok Ho Kang Seoul, Korea, Republic of More articles by this author , Seok-Soo ByunSeok-Soo Byun Seoul, Korea, Republic of More articles by this author , Hyo Sin KimHyo Sin Kim Seoul, Korea, Republic of More articles by this author , and Sung-Hoo HongSung-Hoo Hong Seoul, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.2666AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Many studies have been revealed the changes in renal function after renal surgery from many aspects. However, there are few studies investigating the influencing factors on changes in postoperative renal function depending on different surgical methods such as radical nephrectomy or partial nephrectomy. The authors of this study investigated on the factors affecting changes in postoperative renal function after conducting radical nephrectomy or partial nephrectomy. METHODS Data on 2454 patients who underwent operation for renal cell carcinoma between 2000 and 2010 in multiple institutions were collected. Patient characteristics including age, sex, body weight, height, diabetes or hypertension, and preoperative estimated GFR(EGFR) were investigated. Types of surgery and perioperative results were evaluated. Renal insufficiency is defined as an EGFR of less than 60 mL/min and a serum creatinine level of below 2.0 mg/dL. Multivariate logistic regression analysis was used to investigate which factors were associated with chronic renal insufficiency after the operation. RESULTS The number of patients with nephrectomy was 1,502 and with partial nephrectomy was 952. The average follow-up period was 44.48¡¾27.04 (12-120) months. In preoperative data analysis, there were significant differences between two groups in age (p=0.0013), diabetes (p=0.0094), hypertension (p=0.0066), EGFR (p<0.001) and calcium level (p=0.0265). In subgroup analysis, factors affecting EGFR were the age, gender, hypertension, surgical methods, preoperative creatinine level and EGFR (p<0.001). Surgical methods, diabetes, hypertension were established to have great influences on the postoperative EGFR decrease. The age over 58 year, EGFR±73, and Cr>1.03 was the cut-off point in case of developing to renal failure after renal surgery. CONCLUSIONS The risk for postoperative renal insufficiency was verified to be higher in patients of radical nephrectomy group than in partial nephrectomy group. Moreover, we were able to identify other factors affecting renal insufficiency including diabetes, hypertension, preoperative creatinine, and others. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e536 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Yong Sun Choi Seoul, Korea, Republic of More articles by this author Yong Hyun Park Seoul, Korea, Republic of More articles by this author Yong-June Kim Seoul, Korea, Republic of More articles by this author Seok Ho Kang Seoul, Korea, Republic of More articles by this author Seok-Soo Byun Seoul, Korea, Republic of More articles by this author Hyo Sin Kim Seoul, Korea, Republic of More articles by this author Sung-Hoo Hong Seoul, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...