131 Differences in Androgen Levels and Sexual Function between North American and European Men

Abstract

Previous studies have indicated sex steroid levels vary by geographic location, suggesting environmental factors may play a role in hormone production. Despite this, few studies have evaluated the association of androgen levels and sexual function with geographic location. To identify the differences in baseline androgen levels and sexual function between North American and European men in the Reduction by Dutasteride in Prostate Cancer Events (REDUCE) Study. We evaluated data of 5,825 men in the REDUCE study, which included subjects aged 50-75 years with prostate-specific antigen levels of 2.5-10 ng/mL (50-60 years) or 3.0-10 ng/mL (60-75 years) and a negative baseline prostate biopsy. Subjects were divided in two groups: North Americans and Europeans. Differences in baseline demographics, comorbidities, laboratory results and questionnaire-based sexual function (Problem Assessment Scale of Sexual Function Index: PAS-SFI) between groups were evaluated using analysis of variance and chi-square tests in univariable analysis, and linear and logistic regressions in multivariable analysis. Subgroup analyses further dividing Europeans into Eastern and Western were performed as above.