Abstract
Introduction Links between endorphins and dopaminergic transmission have not been fully explored in schizophrenia. Objectives Both endorphins excess and deficiency were postulated in schizophrenia. CGRP is probably involved in dopaminergic transmission. Aims Evaluation of β-endorphin and CGRP blood concentrations before and after treatment of severe schizophrenia. Methods 70 patients treated with various antipsychotics, with severe symptoms of schizophrenia (51 with positive symptoms, 19 with negative symptoms), 15 first degree relatives and 44 healthy controls were included to the study. β-endorphin and CGRP blood concentrations were measured in severe schizophrenia and in stable mental state. The results were compared with relatives and controls. Results β-endorphin and CGRP concentrations in patients with negative symptoms were higher than in relatives and controls. β-endorphin levels in patients with positive symptoms were lower than in patients with negative symptoms (p Conclusions Effective antipsychotic treatment results in “normalization” of β-endorphin level. Specific changes in β-endorphin concentration could be involved in dopaminergic transmission and related to some symptoms of schizophrenia.
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