1305P - Factors Predicting Brain Metastases in Patients with Non-Small Cell Lung Cancer

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ABSTRACT Purpose Brain metastases (BM), a common complication of non-small cell lung cancer (NSCLC), usually lead to a poor prognosis. Recent advances in BM therapy modesly prolong the survival after BM diagnosis in a subset of patients. Selection of treatment modalities for BM is based largely on the number of BM, BM-related symptoms and patient's functional performance status. Therfore, early dection of BM in high-risk patients is crucial. In this study, we sough to elucidate the factors predicting BM. Methods and patients Medical records of patients with stage 1-4 NSCLC were retrospectively reviewed for the period between January 2006 and December 2011 under the approval of the joint institutional review board. Clinical demographic data, histology, stage of disease, presence of BM, survial were collected and analyzed. A multivariate logistic regression model was used to identiy the predictors of BM. Results Among 596 NSCLC patients with a mean follow-up time of 12.5± 12.5 months and a mortality rate of 62% at the last follow up, 187 (31%) experienced BM during their disease course. The accumulative incidence of BM was higher in patients with adenocarcinoma (ADC) than those with squamous cell carcinoma (SCC) (36% vs 13%, p Conclusion We find that gender, age and histological subtype are independent factors predicting BM in NSCLC patients and suggest identification of patients at high risks for BM might help detect BM earlier and facilitate the design of clinical trials aming at the prevention of BM. Disclosure All authors have declared no conflicts of interest.