Abstract
Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS) is a potentially life-threatening cutaneous adverse reaction to a drug and/or its metabolites. Despite being a relatively common severe cutaneous drug eruption, the histopathology of DRESS/DIHS is poorly characterized1. Various histopathologic features of patients diagnosed with DRESS/DIHS have been described. The present study sought to characterize the histopathologic findings of DRESS cases diagnosed at the University of Colorado Hospital from September 2008-September 2018 and determine correlation to culprit drug and clinical characteristics.
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