Abstract
The ability to arm oncolytic vectors with transgenes gives researchers a mechanism for potential improvements in the vector potency. However, depending on the method for transgene insertion, the growth and selectivity of the oncolytic vector may be affected, ultimately reducing the efficacy of the vector. Here, a novel approach of inserting transgenes into various regions of the Ad5 genome that utilizes the Ad5 transcriptional machinery to allow high levels of transgene expression with minimal effect on the growth, cytotoxicity or selectivity of the vectors is described.
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