Abstract
The discovery of dental stem cells provided a new avenue for cell-based tissue engineering and regeneration of dental tissues. These dental tissue–derived mesenchymal stem/stromal cells (MSCs) share characteristics similar to other MSCs, yet, they are subtly different. They are relatively robust stem/progenitor cells, and these cells can proliferate many times in cultures, reaching a large number from a small population at the time of isolation. Since their discovery, tremendous progress has been made demonstrating their potential in dental tissue regeneration in small and large animal models. This chapter will review the recent studies on the characteristics of several dental stem cells and their potential tissue regeneration potential including pulp dentin, periodontal tissue, and whole tooth regeneration.
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