Abstract
Beta-cell mass and function are under the control of metabolic, hormonal and neural signals, many of which act via G protein-coupled receptors (GPCRs). Regulator of G protein signalling 9 (RGS9) couples with Galphai and is expected to reduce and terminate signals from inhibitory GPCRs. In this study, we test the hypothesis that RGS9 reduces the inhibitory GPCR signal for beta-cell proliferation and insulin secretion.
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